Reacción #336434

Ecuación de reacción

p-cyanoaniIine

4-chloro-3-nitropyridine

→

title compound

Rendimiento 86.6%

4-[N-(4-Cyanophenyl)amino]-3-nitropyridine

Rendimiento 86.6%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónfiltered The solid
2. 2
   workup.ADDITIONwas treated with 150 ml of boiling ethanol
3. 3
   Temperaturacooled in ice
4. 4
   Filtraciónfiltered

Procedimiento

According to the method of J.C.S. Perkin Trans. I, 1979, 135, p-cyanoaniIine (6 894 g, 58.4 mmol) was added to a solution of 4-chloro-3-nitropyridine (9.26 g, 58.4 mmol) in ethanol (200 ml) and the mixture was stirred at room temperature for 18 hours. The resulting yellow suspension was poured into 500 ml of ice-cold dilute ammonia and filtered The solid was treated with 150 ml of boiling ethanol, cooled in ice, and filtered to give the title compound as a bright yellow powder, (12.15 g), m.p. 210°-211° C.

Fuente