Reacción #336045

Ecuación de reacción

methyl isocyanate

4-(2,3,4,5,6-pentafluorophenoxy)piperdine hydrochloride

triethylamine

→

1-[(N-methylamino)carbonyl]-4-(2,3,4,5,6-pentafluorophenoxy)piperidine

Rendimiento 93.3%

Disolventes

benzene

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroevaporated to a semi-solid
2. 2
   OtroThe semi-solid was purified by means of high pressure liquid chromatography (silica gel; elution with 50% ethyl acetate/dichloromethane)

Procedimiento

To a stirring solution of 5.3 g of 4-(2,3,4,5,6-pentafluorophenoxy)piperdine hydrochloride in 100 ml of benzene was added 2.37 ml of triethylamine followed by 1.00 ml of methyl isocyanate. The reaction mixture was stirred at ambient temperature for three hours and then evaporated to a semi-solid. The semi-solid was purified by means of high pressure liquid chromatography (silica gel; elution with 50% ethyl acetate/dichloromethane) to afford 5.14 g (93.3%) of 1-[(N-methylamino)carbonyl]-4-(2,3,4,5,6-pentafluorophenoxy)piperidine, m.p. 107°-110° C.

Fuente