Reacción #335653

Ecuación de reacción

2-(5-chloro-3-methylbenzo[b]-thien-2-yl)piperazine

7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

→

desired product

7-[3-(5-Chloro-3-methylbenzo[b]thien-2-yl)-1-piperazinyl]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture was heated in a pressure bottle, under argon at 130°-135° C. for 18 hours
2. 2
   Temperaturacooled
3. 3
   Otroplaced in an ice bath
4. 4
   OtroThe resulting crystals were collected
5. 5
   Lavadowashed with cold pyridine, dichloromethane and ether
6. 6
   Otrorecrystallized from dimethylformamide

Procedimiento

A 3.0 g portion of 2-(5-chloro-3-methylbenzo[b]-thien-2-yl)piperazine was added to 5 ml of pyridine. A 1.01 g portion of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid was added and the mixture was heated in a pressure bottle, under argon at 130°-135° C. for 18 hours, then cooled and placed in an ice bath. The resulting crystals were collected, washed with cold pyridine, dichloromethane and ether and recrystallized from dimethylformamide, giving 401 mg of the desired product, mp 300°-305° C.

Fuente