Reacción #335361

ord-16924eae082040dfa40f50968e53f5ae

Ecuación de reacción

ClCc1csc(-c2ccccc2)n1
2-phenyl-4-(chloromethyl)thiazole
CC(C(=O)O)c1ccc2cc(O)ccc2c1
racemic 6-hydroxy-α-methyl-2-naphthaleneacetic acid
→
CC(C(=O)O)c1ccc2cc(OCc3csc(-c4ccccc4)n3)ccc2c1
title compound
CC(C(=O)O)c1ccc2cc(OCc3csc(-c4ccccc4)n3)ccc2c1
α-Methyl-6-[(2-phenyl-4-thiazolyl)methoxy]-2-naphthaleneacetic acid

Reactantes

ClCc1csc(-c2ccccc2)n1
2-phenyl-4-(chloromethyl)thiazole
CC(C(=O)O)c1ccc2cc(O)ccc2c1
racemic 6-hydroxy-α-methyl-2-naphthaleneacetic acid

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroWhite crystals are obtained

Procedimiento

The title compound is prepared according to the method of Example 7 using 2-phenyl-4-(chloromethyl)thiazole and racemic 6-hydroxy-α-methyl-2-naphthaleneacetic acid. White crystals are obtained having a melting point of 163°-164° C.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05208344uspto-grants-1993_05