Reacción #335019

Ecuación de reacción

N-[2,6-bis(1-methylethyl)phenyl]-2-[(phenylmethyl)amino]acetamide

→

title compound

Rendimiento 80.2%

N-[2,6-Bis(1-methylethyl)phenyl]-2-aminoacetamide

Rendimiento 80.2%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónAfter filtration and concentration, flash chromatography (ethyl acetate)

Procedimiento

To a solution of N-[2,6-bis(1-methylethyl)phenyl]-2-[(phenylmethyl)amino]acetamide (Example V) (0.80 g, 2.5 mmol) in methanol (10 mL) is added 20% Pd/C (0.1 g). The mixture is stirred under an atmosphere of hydrogen for 20 hours. After filtration and concentration, flash chromatography (ethyl acetate) affords 0.47 g of the title compound as a white solid; mp 88°-95° C.

Fuente