Reacción #335018

Ecuación de reacción

2,6-diisopropylaniline

sodium acetate trihydrate

bromoacetyl bromide

→

title compound

Rendimiento 86.8%

N-[2,6-Bis(1-methylethyl)phenyl]-2-bromoacetamide

Rendimiento 86.8%

Disolventes

water

acetone

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONis added dropwise
2. 2
   Filtraciónthe product filtered
3. 3
   Lavadowashed with cold water, sodium bicarbonate solution, water
4. 4
   OtroThe product is dried in a vacuum at 40° C.

Procedimiento

To a well-stirred ice-cooled mixture of 2,6-diisopropylaniline (10.0 g, 0.056 mol) in acetone (25 mL) and water (25 mL) and sodium acetate trihydrate (15.3 g, 0.112 mol), bromoacetyl bromide (17.0 g, 0.084 mol) is added dropwise. The reaction mixture is allowed to warm to room temperature and stirred for 1 hour. The reaction mixture is diluted with water (100 mL), the product filtered, washed with cold water, sodium bicarbonate solution, water, and finally with hexane. The product is dried in a vacuum at 40° C. to afford 14.5 g of the title compound as a white solid; mp I70° C.

Fuente