Reacción #335016

Ecuación de reacción

N-[2,6-bis(1-methylethyl)phenyl]-2-acetoxyacetamide

sodium hydroxide

→

title compound

Rendimiento 94.9%

N-[2,6-Bis(1-methylethyl)phenyl]-2-hydroxyacetamide

Rendimiento 94.9%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe mixture is concentrated
2. 2
   workup.ADDITIONdiluted with water
3. 3
   Extracciónextracted three times with ethyl acetate
4. 4
   LavadoThe combined organic extracts are washed with brine
5. 5
   Secadodried over magnesium sulfate
6. 6
   Concentraciónconcentrated

Procedimiento

To a solution of N-[2,6-bis(1-methylethyl)phenyl]-2-acetoxyacetamide (Example N) (5.7 g, 20.6 mmol) in methanol (50 mL) is added 2M sodium hydroxide solution (20 mL). The solution is stirred at room temperature for 1 hour. The mixture is concentrated, diluted with water, and extracted three times with ethyl acetate. The combined organic extracts are washed with brine, dried over magnesium sulfate, and concentrated to afford 4.6 g of the title compound as an off-white solid; mp 164°-166° C.

Fuente