Reacción #334986

Ecuación de reacción

hydrochloric acid

2-fluoro-4-hydroxybenzoic acid

tridecanoyl chloride

dimethylaminopyridine

→

titled compound

Rendimiento 59.4%

2-fluoro-4-n-tridecanoyloxybenzoic acid

Rendimiento 59.4%

Disolventes

dichloromethane

triethylamine

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe organic layer was separated by a funnel
2. 2
   workup.DISTILLATIONdistilled
3. 3
   Otroto remove the solvent
4. 4
   LavadoThe residue was washed with n-hexane
5. 5
   Otrodried

Procedimiento

To a solution of 2-fluoro-4-hydroxybenzoic acid (1.4 g) and triethylamine (1.0 g) in dichloromethane (40 ml) were added tridecanoyl chloride (2.0 g) and dimethylaminopyridine (0.2 g). The solution was stirred at room temperature for about 20 hours and thereto was added dilute aqueous hydrochloric acid solution. The organic layer was separated by a funnel and distilled to remove the solvent. The residue was washed with n-hexane and dried to obtain the titled compound (about 1.8 g).

Fuente