Reacción #334985

Ecuación de reacción

hydrochloric acid

2-fluoro-4-hydroxybenzoic acid

decanoylchloride

dimethylaminopyridine

→

titled compound

Rendimiento 70.4%

2-fluoro-4-n-decanoyloxybenzoic acid

Rendimiento 70.4%

Disolventes

dichloromethane

triethylamine

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe organic layer was separated by a funnel
2. 2
   workup.DISTILLATIONThe layer was distilled
3. 3
   Otroto remove the solvent
4. 4
   LavadoThe residue was washed with n-hexane
5. 5
   Otrodried

Procedimiento

To a solution of 2-fluoro-4-hydroxybenzoic acid (2 g) and triethylamine (1.4 g) in dichloromethane (40 ml) were added decanoylchloride (2.7 g) and dimethylaminopyridine (0.2 g). The solution was stirred at room temperature for about 20 hours. To the solution was added dilute aqueous hydrochloric acid solution and the organic layer was separated by a funnel. The layer was distilled to remove the solvent. The residue was washed with n-hexane and dried to obtain the titled compound (about 2.8 g).

Fuente