Reacción #334672

Ecuación de reacción

benzyl 6-(2,2,2-trifluoro-1-hydroxyethyl)-3-morpholino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate

charcoal

sodium bicarbonate

dioxane

→

sodium 6-(2,2,2-trifluoro-1-hydroxyethyl)-3-morpholino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe mixture is filtered
2. 2
   Otroto remove the catalyst which
3. 3
   Lavadois washed with water (3×2 ml)
4. 4
   ExtracciónThe combined filtrate is extracted with ethyl acetate (2×2 ml)
5. 5
   Concentraciónconcentrated in vacuo

Procedimiento

A mixture of benzyl 6-(2,2,2-trifluoro-1-hydroxyethyl)-3-morpholino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate (25 mg), 10% palladium on powdered charcoal (25 mg), sodium bicarbonate (5 mg), dioxane (2 ml), and water (1 ml) is hydrogenated at 40 psi for 30 mins. The mixture is filtered to remove the catalyst which is washed with water (3×2 ml). The combined filtrate is extracted with ethyl acetate (2×2 ml), concentrated in vacuo, and lyophilized to give sodium 6-(2,2,2-trifluoro-1-hydroxyethyl)-3-morpholino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate.

Fuente