Reacción #3315

Ecuación de reacción

ethylamine

4-chloro-2-methylthio-5-pyrimidinecarboxylate ethyl ester

triethylamine

→

4-ethylamino-2-methylthio-5-pyrimidinecarboxylate ethyl ester

Rendimiento 90.0%

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated in vacuo
2. 2
   Otropartitioned between chloroform and saturated aqueous sodium bicarbonate
3. 3
   SecadoThe organic layer was dried over magnesium sulfate
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated

Procedimiento

To a room temperature solution of 4-chloro-2-methylthio-5-pyrimidinecarboxylate ethyl ester (10.00 g, 43.10 mmol) in 150 mL of tetrahydrofuran was added triethylamine (18.5 mL, 133 mmol) followed by 9 mL of a 70% aqueous solution of ethylamine. The solution was stirred for 30 minutes, then concentrated in vacuo and partitioned between chloroform and saturated aqueous sodium bicarbonate. The organic layer was dried over magnesium sulfate, filtered, and concentrated to provide 9.32 g (90%) of 4-ethylamino-2-methylthio-5-pyrimidinecarboxylate ethyl ester as an oil.

Fuente