Reacción #331462

Ecuación de reacción

2-bromopyridin-3-ol

1-bromo-2-fluoroethane

K2CO3

→

28

Rendimiento 68.0%

2-bromo-3-(2-fluoroethoxy)pyridine

Rendimiento 68.0%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat refluxing for one day until TLC
2. 2
   Filtraciónfilter
3. 3
   Otrodried
4. 4
   Concentraciónconcentrated
5. 5
   OtroThe crude product was purified with column chromatography

Procedimiento

A mixture of 2-bromopyridin-3-ol 27 (0.1 mmol), 1-bromo-2-fluoroethane (0.2 mmol) and K2CO3 (0.4 mmol) in acetonitrile were stirred at refluxing for one day until TLC indicated that the reaction was complete, and then filter, dried and concentrated under reduce pressure. The crude product was purified with column chromatography to afforded 28 (yield, 68%). 1H NMR (CDCl3): δ 4.25-4.34 (m, 2H), 4.73-4.89 (m, 2H), 7.20-7.22 (m, 2H), 8.01 (s, 1H).

Fuente