Reacción #331108

ord-67ecc4df59ce43ed84db0f6eff41d32e

Ecuación de reacción

c1ccc(-c2ccnc(N3CC4CNCC4C3)n2)cc1
Intermediate 26
c1ccc(-c2ccnc(N3CC4CNCC4C3)n2)cc1
2-(4-Phenyl-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole
O=C(O)c1ccccc1Br
2-bromobenzoic acid
→
O=C(c1ccccc1Br)N1CC2CN(c3nccc(-c4ccccc4)n3)CC2C1
title compound
O=C(c1ccccc1Br)N1CC2CN(c3nccc(-c4ccccc4)n3)CC2C1
2-[(2-Bromophenyl)carbonyl]-5-(4-phenylpyrimidin-2-yl)octahydropyrrolo[3,4-c]pyrrole

Reactantes

c1ccc(-c2ccnc(N3CC4CNCC4C3)n2)cc1
Intermediate 26
c1ccc(-c2ccnc(N3CC4CNCC4C3)n2)cc1
2-(4-Phenyl-pyrimidin-2-yl)-octahydro-pyrrolo[3,4-c]pyrrole
O=C(O)c1ccccc1Br
2-bromobenzoic acid

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 26 and 2-bromobenzoic acid. MS (ESI) mass calcd. for C23H21BrN4O, 449.34; m/z found, 449.1, 451.1 [M+H]+.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08653263B2uspto-grants-2014_02