Reacción #329314

Ecuación de reacción

(2,2-difluoro-1,3-benzodioxol-5-yl)-acetonitrile

KOH

MTBE

→

(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarbonitrile

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture is cooled
2. 2
   LavadoThe organic phase is washed with water and brine
3. 3
   Otrothe solvent is removed

Procedimiento

A mixture of (2,2-difluoro-1,3-benzodioxol-5-yl)-acetonitrile (1.0 eq), 50 wt % aqueous KOH (5.0 eq) 1-bromo-2-chloroethane (1.5 eq), and Oct4NBr (0.02 eq) is heated at 70° C. for 1 h. The reaction mixture is cooled then worked up with MTBE and water. The organic phase is washed with water and brine then the solvent is removed to afford (2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarbonitrile.

Fuente