Reacción #327694

ord-a36b15c9e78444f79dd4908c5c6b1874

Ecuación de reacción

CC(C)(C)OC(=O)N1C[C@@H]2CN(c3cncc(C(=O)O)c3)C[C@@H]2C1
product
CC(C)(C)OC(=O)N1C[C@@H]2CN(c3cncc(C(=O)O)c3)C[C@@H]2C1
5-((3aR,6aS)-5-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)nicotinic Acid
Cc1cc(C)cc(N)c1
3,5-dimethylaniline
→
Cc1cc(C)cc(NC(=O)c2cncc(N3C[C@H]4CN(C(=O)OC(C)(C)C)C[C@H]4C3)c2)c1
title compound
Cc1cc(C)cc(NC(=O)c2cncc(N3C[C@H]4CN(C(=O)OC(C)(C)C)C[C@H]4C3)c2)c1
(3aR,6aS)-tert-butyl 5-(5-(3,5-dimethylphenylcarbamoyl)pyridin-3-yl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

Reactantes

CC(C)(C)OC(=O)N1C[C@@H]2CN(c3cncc(C(=O)O)c3)C[C@@H]2C1
product
CC(C)(C)OC(=O)N1C[C@@H]2CN(c3cncc(C(=O)O)c3)C[C@@H]2C1
5-((3aR,6aS)-5-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)nicotinic Acid
Cc1cc(C)cc(N)c1
3,5-dimethylaniline

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The product from Example 33B and 3,5-dimethylaniline were processed as described in Example 33C to provide the title compound. MS (APCI) m/z 337 (M+H)+.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08648084B2uspto-grants-2014_02