Reacción #325553

Ecuación de reacción

2-methyl-1′H,2H-3,4′-bipyrazole

4-iodobenzotrifluoride

potassium carbonate

trans-N,N′-dimethylcyclohexan-1,2-diamine

ammonium chloride

→

title compound

Rendimiento 80.7%

2-Methyl-1′-[4-(trifluoromethyl)phenyl]-1′H,2H-3,4′-bipyrazole

Rendimiento 80.7%

Disolventes

N,N-dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe obtained mixture was then extracted with chloroform
2. 2
   SecadoThe organic layer was dried over anhydrous magnesium sulfate
3. 3
   Concentraciónwas then concentrated under a reduced pressure
4. 4
   OtroThe residue was purified by column chromatography (silica gel cartridge, hexane:ethyl acetate=9:1 to 1:1)

Procedimiento

Under a nitrogen atmosphere, a mixture of 2-methyl-1′H,2H-3,4′-bipyrazole (176 mg), 4-iodobenzotrifluoride (485 mg), copper iodide (45 mg), potassium carbonate (329 mg), trans-N,N′-dimethylcyclohexan-1,2-diamine (135 mg) and N,N-dimethylformamide (2.2 mL) was stirred at 100° C. for 16 hours. Thereafter, a saturated ammonium chloride aqueous solution was added to the reaction solution, and the obtained mixture was then extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate, and was then concentrated under a reduced pressure. The residue was purified by column chromatography (silica gel cartridge, hexane:ethyl acetate=9:1 to 1:1), so as to obtain the title compound (280 mg) in the form of a colorless solid.

Fuente