Reacción #324681

Ecuación de reacción

3-Bromo-2-methylphenol

3-(methylthio)propanol

tri-n-butyl phosphine

1,1′-(azodicarbonyl)dipiperidine

→

product

(3-(3-Bromo-2-methylphenoxy)propyl)(methyl)sulfane

Disolventes

Water

tetrahydrofurane

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe mixture extracted with diethyl ether
2. 2
   LavadoThe organic layer is washed with brine
3. 3
   Secadodried (Na2SO4)
4. 4
   Otrovolatiles removed under reduced pressure

Procedimiento

3-Bromo-2-methylphenol (0.10 g), 3-(methylthio)propanol (0.055 mL), tri-n-butyl phosphine (0.12 g) and 1,1′-(azodicarbonyl)dipiperidine (0.15 g) are stirred in tetrahydrofurane for 16 hours. Water is added and the mixture extracted with diethyl ether. The organic layer is washed with brine, dried (Na2SO4) and volatiles removed under reduced pressure. The product (80 mg) is obtained after column chromatography (silica gel, n-hexane/ethyl acetate gradient 100:0 to 50:50).

Fuente