Reacción #324356

Ecuación de reacción

aniline

N,N-diisopropylethylamine

propane sultone

→

di[ethyl(diisopropyl)ammonium] 3-(3-sulfonatopropylanilino)-1-propanesulfonate

Rendimiento 94.0%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was evaporated
2. 2
   workup.ADDITIONethylacetate was added
3. 3
   FiltraciónThe precipitated DIPEA bromide was filtered off
4. 4
   Otrothe filtrate was evaporated
5. 5
   workup.ADDITIONThe residue was treated with ether

Procedimiento

A mixture of aniline (7 mmol), N,N-diisopropylethylamine (DIPEA, 18 mmol) and propane sultone (16 mmol) was heated in a pressure tube in 10 mL of acetonitrile at 120-130° C. for 9 h under argon atmosphere. The solvent was evaporated and ethylacetate was added. The precipitated DIPEA bromide was filtered off and the filtrate was evaporated. The residue was treated with ether to give di[ethyl(diisopropyl)ammonium] 3-(3-sulfonatopropylanilino)-1-propanesulfonate as a white or pinky-white solid. Yield: 94%.

Fuente