Reacción #324165

ord-663b0618c75145368eab0ce7fa61ecd4

Ecuación de reacción

C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]12
Vitamin D3
II
iodine
→
C=C1CC[C@H](O)C/C1=C\C=C1/CCC[C@@]2(C)C1CC[C@@H]2[C@H](C)CCCC(C)C
trans-vitamin D3
Rendimiento 61.3%

Reactantes

C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]12
Vitamin D3
II
iodine

Reactivos

Ninguno

Disolventes

CCCCCC
hexane

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Lavadoat 20° the solution was washed with aqueous sodium thiosulphate, water
  2. 2
    Secadodried over sodium sulphate
  3. 3
    OtroAfter removal of the solvent, chromatography

Procedimiento

To a solution of Vitamin D3 (750 mgs) in hexane (20 ml) was added iodine (2 mgs). After stirring for 1 hr. at 20° the solution was washed with aqueous sodium thiosulphate, water and dried over sodium sulphate. After removal of the solvent, chromatography afforded trans-vitamin D3 (460mgs).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04159326uspto-grants-1979_06