Reacción #323881

Ecuación de reacción

phosgene

1,2-methylenedioxybenzene

N-methylformanilide

→

1,2-methylenedioxybenzene

piperonal

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONThereafter, the resulting mixture was treated in the same manner as in Example 1

Procedimiento

Into a mixture of 97.7 g (0.80 mole) of 1,2-methylenedioxybenzene and 108 g (0.80 mole) of N-methylformanilide was introduced 80.0 g (0.81 mole) of phosgene at 50° C. over a 1-hour period. Then, the reaction mixture was heated at 70° C. for 5 hours, poured into ice water, and allowed to stand for 1 hour. Thereafter, the resulting mixture was treated in the same manner as in Example 1 to obtain 48.0 g (0.393 mole) of 1,2-methylenedioxybenzene and 58.9 g (0.392 mole) of piperonal. The yield and selectivity of piperonal were 49.0% and 96.3%, respectively. The recoveries of N-methylaniline and N-methylformanilide were 64.2% and 2.3%, respectively.

Fuente