Reacción #323710

Ecuación de reacción

4-methyl-3-thiophenesulfonyl isocyanate

2-amino-4,6-dimethoxypyrimidine

→

desired product

Rendimiento 43.3%

N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-4-methyl-3-thiophenesulfonamide

Rendimiento 43.3%

Disolventes

acetonitrile

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGThe mixture was stirred for 16 hours at ambient temperature
2. 2
   Filtraciónfiltered

Procedimiento

A solution of 2 g of 4-methyl-3-thiophenesulfonyl isocyanate in 5 ml of dry acetonitrile was added to 1.5 g of 2-amino-4,6-dimethoxypyrimidine in 20 ml of acetonitrile with stirring. The mixture was stirred for 16 hours at ambient temperature and filtered to yield 1.5 g of the desired product, m.p. 175°-178°.

Fuente