Reacción #323435

Ecuación de reacción

hydrochloric acid isopropanol

thiourea

5-(dimethylamino)methyl-4-methyl-2-thenyl alcohol

→

2-amidinothiomethyl-5-(dimethylamino)methyl-4-methylthiophene dihydrochloride

Rendimiento 82.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   Otroafter which the resulting mixture was subjected to reaction
3. 3
   Temperaturaunder reflux for 15 hours
4. 4
   Otroto stand at room temperature
5. 5
   Filtraciónthe crystals deposited were collected by filtration

Procedimiento

In 35 ml of 21% (by weight) hydrochloric acid-isopropanol solution was suspended 2.1 g of thiourea, and 5 g of 5-(dimethylamino)methyl-4-methyl-2-thenyl alcohol was added thereto, after which the resulting mixture was subjected to reaction under reflux for 15 hours. After the mixture was allowed to stand at room temperature, the crystals deposited were collected by filtration to obtain 7 g (yield 82%) of 2-amidinothiomethyl-5-(dimethylamino)methyl-4-methylthiophene dihydrochloride having a melting point of 212°-214° C. (decomp.).

Fuente