Reacción #322961

ord-a8960d59cebc469091e2f3f196126c97

Ecuación de reacción

CN1CCCC1c1cccnc1
nicotine
OO
hydrogen peroxide
O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
→
C[N+]1([O-])CCCC1c1cccnc1
nicotine N'-oxide

Reactantes

CN1CCCC1c1cccnc1
nicotine
OO
hydrogen peroxide
O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid

Reactivos

Ninguno

Condiciones de reacción

Temperatura
80°CELSIUS
Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Temperaturathe temperature being maintained below 90° C
  2. 2
    workup.ADDITIONAfter the addition

Procedimiento

500 g of nicotine (3.08 mol) are slowly added dropwise to an equimolar 30% hydrogen peroxide solution containing 5.9 g of citric acid (30.8 mmol), the temperature being maintained below 90° C. After the addition has ended, the mixture is heated at 80° C. for 5 hours.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04641667uspto-grants-1987_02