Reacción #322295

Ecuación de reacción

7-amino-1-(4-methyl-1-piperazinyl)-naphthalene

triethylamine

3,5-dinitrobenzoyl chloride

→

title compound

Rendimiento 63.0%

7-(3,5-Dinitrobenzamido)-1-(4-methyl-1-piperazinyl)-naphthalene

Rendimiento 63.0%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe title product was prepared
2. 2
   Otrowith overnight
3. 3
   OtroThe product was purified
4. 4
   Otrochromatography and recrystallization from acetonitrile

Procedimiento

The title product was prepared following the procedure of example 3 from 7-amino-1-(4-methyl-1-piperazinyl)-naphthalene (0.15 g, 0.622 mmol) and triethylamine (0.09 mL, 0.68 mmol) and 3,5-dinitrobenzoyl chloride (0.158 g, 0.684 mmol) in acetonitrile (10 mL) with overnight stirring at room temperature. The product was purified using chromatography and recrystallization from acetonitrile to yield 0.17 g (63%) of the title compound: mp 254°-256° C. Analysis calculated for C22H21N5O5 : C, 60.68; H, 4.86; N, 16.08. Found: C, 60.59; H, 4.73; N, 15.88.

Fuente