Reacción #322061

Ecuación de reacción

potassium hydroxide

4-amino-5-formyl-2-methylpyrimidine

2-acetylthiophene

→

2-Methyl-7-(2-thienyl)-pyrido[2,3-d]pyrimidine

Rendimiento 17.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas removed After the residue
2. 2
   Lavadothe organic phase was washed with water
3. 3
   Otrodried
4. 4
   Otroevaporated down

Procedimiento

1 ml of 40% strength by weight aqueous potassium hydroxide solution was added to a suspension of 2.0 g (14.6 mmol) of 4-amino-5-formyl-2-methylpyrimidine and 1.93 g. (15.3 mmol) of 2-acetylthiophene in 25 ml of methanol. The reaction mixture was then stirred for 20 hours at 20°-25° C. after which the solvent was removed After the residue had been taken up in dichloromethane, the organic phase was washed with water, dried and evaporated down. Yield: 17%; mp.: 175°-180° C.

Fuente