Reacción #322060

Ecuación de reacción

potassium hydroxide

4-amino-5-formyl-2-methylpyrimidine

4-fluoroacetophenone

→

7-(4-Fluorophenyl)-2-methylpyrido[2,3-d]pyrimidine

Rendimiento 50.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroa homogeneous solution being formed
2. 2
   Otrothe solid formed
3. 3
   Otrowas isolated
4. 4
   Otrowas recrystallized from ethanol

Procedimiento

15 ml of 40% strength by weight aqueous potassium hydroxide solution were slowly added to a suspension of 30.1 g (0.22 mol) of 4-amino-5-formyl-2-methylpyrimidine and 31.7 g (0.23 mol) of 4-fluoroacetophenone in 395 ml of methanol at 20°-25° C., a homogeneous solution being formed. After the mixture had been stirred for 20 hours at about 20° C., the solid formed was isolated and was recrystallized from ethanol. Yield: 50%; mp.>200° C.

Fuente