Reacción #321803

Ecuación de reacción

4-bromo-1,2-methylenedioxybenzene

1,4-cyclohexanedione monoethylene ketal

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product

Rendimiento 52.0%

8-(1,3-Benzodioxol-5-yl)-1,4-dioxaspiro[4,5]decan-8-ol

Rendimiento 52.0%

Disolventes

THF

Condiciones de reacción

Procedimiento

A solution of 1,4-cyclohexanedione monoethylene ketal in dry THF was reacted with the Grignard reagent prepared from 4-bromo-1,2-methylenedioxybenzene as described in example 1 to give the product (52%, mp: 95°-96° C.). Calc'd for C15H18O2 : C, 64.74%; H, 6.52%. Found: C, 64.41%; H, 6.41%.

Fuente