Reacción #321645

Ecuación de reacción

1-napthaleneboronic acid

N-(5-bromothiophene-2-sulfonyl)pyrrole

→

N-[5-(1-napthyl)thiophene-2-sulfonyl]pyrrole

Rendimiento 87.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroPurification by column chromatography

Procedimiento

N-[5-(1-napthyl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner as described in Example 32C from 1-napthaleneboronic acid (353 mg, 2.05 mmol) and N-(5-bromothiophene-2-sulfonyl)pyrrole (600 mg, 2.05 mmol). Purification by column chromatography using 2% ethyl acetate/hexanes gave the pure sulfonamide in 87% yield as a pale yellow clear oil.

Fuente