Reacción #3210

Ecuación de reacción

water

sodium hydroxide

5-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione

→

title compound

Rendimiento 94.0%

Methyl 2-amino-6-methoxybenzoate

Rendimiento 94.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled to room temperature
2. 2
   ExtracciónThe resulting solution was extracted with ethyl acetate
3. 3
   Otrothe combined extracts were dried (Na2 SO4)
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated

Procedimiento

To a stirred solution of sodium hydroxide (0.06 g, 1.5 mM) in methanol (7 mL) under a nitrogen atmosphere was added 5-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione (2.90 g, 15.0 mM). The reaction mixture was stirred at 65° C. for 14.5 hr, cooled to room temperature and poured into water. The resulting solution was extracted with ethyl acetate and the combined extracts were dried (Na2 SO4), filtered and concentrated to provide the title compound (2.55 g, 94%) as a tan oil; MS(CI): 182 (M+H).

Fuente