Reacción #320048

Ecuación de reacción

sodium boron hydride

7-chloro-6-fluoro-2-formylquinoline

→

title compound

Rendimiento 69.4%

7-Chloro-6-fluoro-2-hydroxymethylquinoline

Rendimiento 69.4%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroobtained in Reference example 2
2. 2
   OtroAfter the solvent was removed
3. 3
   Extracciónthe residue was extracted with ice water-methylene chloride
4. 4
   Lavadothe organic layer was washed with water
5. 5
   Secadodried over anhydrous sodium sulfate
6. 6
   OtroAfter the solvent was removed

Procedimiento

3 g of sodium boron hydride was added to 11.19 g of 7-chloro-6-fluoro-2-formylquinoline obtained in Reference example 2 suspended in 250 ml of methanol and the mixture was stirred at room temperature for 1 hour. After the solvent was removed, the residue was extracted with ice water-methylene chloride and the organic layer was washed with water and dried over anhydrous sodium sulfate. After the solvent was removed, the residue was applied to silica gel column chromatography to obtain 7.84 g of the title compound.

Fuente