Reacción #318559

Ecuación de reacción

2,4,6-trichloronitrobenzene

2-(β-aminoethoxy)ethanol

→

4-chloro-2-(β-hydroxyethoxyethyl)amino6-(β-hydroxyethoxyethyl)aminonitrobenzene

Disolventes

dioxan

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturais heated
2. 2
   Temperaturato reflux of the dioxon
3. 3
   OtroThe product expected crystallizes
4. 4
   Lavadowashing with water
5. 5
   Otrodrying
6. 6
   Temperaturaby heating under vacuum
7. 7
   Otrothe product is recrystallized from acetonitrile

Procedimiento

The mixture consisting of 0.1 mole (22.6 g) of 2,4,6-trichloronitrobenzene, 0.6 mole (63 g) of 2-(β-aminoethoxy)ethanol and 20 ml of dioxan is heated to reflux of the dioxon. After 4 hours, the reaction mixture is poured onto to 200 g of ice. The product expected crystallizes on acidifying with concentrated hydrochloric acid. After draining, washing with water and drying by heating under vacuum, the product is recrystallized from acetonitrile and then from toluene. It melts at 83° C.

Fuente