Reacción #318025

Ecuación de reacción

4-Fluoro-2-methyl-1-nitrobenzene

sodium benzenesulfinate

→

title compound

Rendimiento 75.3%

3-Methyl-4-nitrophenyl phenyl sulphone

Rendimiento 75.3%

Disolventes

N,N-dimethylacetamide

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling the mixture
2. 2
   Filtraciónwas filtered
3. 3
   Otrothe filtrate collected
4. 4
   Otrothe solvent removed in vacuo
5. 5
   OtroThe residue was triturated with cyclohexane
6. 6
   Filtraciónthe resultant precipitate collected by filtration

Procedimiento

4-Fluoro-2-methyl-1-nitrobenzene (2.6 g) (available from Aldrich) and sodium benzenesulfinate (3.0 g) (available from Aldrich) were heated in N,N-dimethylacetamide (40 ml) at 50° C. for 16 h. After cooling the mixture was filtered, the filtrate collected and the solvent removed in vacuo. The residue was triturated with cyclohexane and the resultant precipitate collected by filtration to give the title compound as a white solid (3.5 g).

Fuente