Reacción #318013

Ecuación de reacción

Cyclopentanethiol

potassium carbonate

1-fluoro-4-nitrobenzene

→

title compound

Rendimiento 32.1%

1-(Cyclopentylthio)-4-nitrobenzene

Rendimiento 32.1%

Disolventes

acetonitrile

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with ether
2. 2
   LavadoThe organic layer was washed with 1M aqueous sodium hydroxide (20 ml), water (20 ml), and 1M aqueous hydrochoric acid (20 ml)
3. 3
   OtroThe organic layer was separated
4. 4
   Otrothe solvent evaporated in vacuo

Procedimiento

Cyclopentanethiol (1.0 g) (available from Aldrich) was dissolved in acetonitrile (10 ml) and potassium carbonate (1.35 g) was added. After 5 min, 1-fluoro-4-nitrobenzene (1.38 g) (available from Aldrich) was added and the mixture was stirred at room temperature overnight. The mixture was diluted with water and extracted with ether. The organic layer was washed with 1M aqueous sodium hydroxide (20 ml), water (20 ml), and 1M aqueous hydrochoric acid (20 ml). The organic layer was separated and the solvent evaporated in vacuo to give the title compound as a yellow liquid (0.7 g).

Fuente