Reacción #317121

ord-7836256d1ac14ee49b277cc2f5533549

Ecuación de reacción

[Na+].[O]=[Tc](=[O])(=[O])[O-]
sodium pertechnetate
[C-]#[N+]CC(C)(C)OC
MIBI
O.O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+]
sodium citrate dihydrate
Cl.N[C@@H](CS)C(=O)O.O
L-cysteine hydrochloride monohydrate
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
→
[CH-]=NCC(C)(C)OC.[CH-]=NCC(C)(C)OC.[CH-]=NCC(C)(C)OC.[CH-]=NCC(C)(C)OC.[CH-]=NCC(C)(C)OC.[CH-]=NCC(C)(C)OC.[Tc+6]
technetium (99mTc) Sestamibi

Reactantes

[Na+].[O]=[Tc](=[O])(=[O])[O-]
sodium pertechnetate
—
stannous chloride dihydrate
[C-]#[N+]CC(C)(C)OC
MIBI
O.O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+]
sodium citrate dihydrate
Cl.N[C@@H](CS)C(=O)O.O
L-cysteine hydrochloride monohydrate
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The kit includes a lyophilized mixture of a copper complex of MIBI (tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate ([Cu(MIBI)4]BF4)) as the active ingredient, sodium citrate dihydrate as a buffer, L-cysteine hydrochloride monohydrate as a stabilization aid, mannitol as a lyophilization aid, and stannous chloride dihydrate as a reducing agent. Prior to use, the lyophilized mixture is reconstituted with sodium pertechnetate (99mTc) and boiled to form technetium (99mTc) Sestamibi. The U.S. Pharmacopoeia (29th Ed.) requires that a mean of not less than 90% (corrected area percentage) of the total radioactivity is represented by 99mTc-Sestamibi, and a mean of not more than 5% (corrected area percentage) of the total radioactivity is present as 99mTc pentamibi dimethylvinyl isonitrile.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07563920B2uspto-grants-2009_07