Reacción #3164

Ecuación de reacción

2-(aminoethoxy) ethanol

hexahydrophthalic anhydride

→

N-(2-hydroxyethoxyethyl)hexahydrophthalimide

Rendimiento 96.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA 500-ml, two necked flask was equipped with a magnetic stirring bar
2. 2
   Temperaturaheating mantle and condenser
3. 3
   workup.ADDITIONAfter the addition
4. 4
   Temperaturawas refluxed for 12 hours
5. 5
   OtroThe ethanol was removed with a rotoevaporator

Procedimiento

A 500-ml, two necked flask was equipped with a magnetic stirring bar, heating mantle and condenser. The flask was charged with 51 g of 2-(aminoethoxy) ethanol (0.49 mol.) and 250 ml of ethanol. Next, 75 g of hexahydrophthalic anhydride (0.49 mol.) was slowly added to the flask. After the addition was complete the reaction was refluxed for 12 hours. The IR spectrum indicated the reaction was complete. The ethanol was removed with a rotoevaporator to yield 113 g (96%) of N-(2-hydroxyethoxyethyl)hexahydrophthalimide.

Fuente