Reacción #316039

Ecuación de reacción

hydrochloric acid

Sodium hydroxide

water

5-Fluoro-1H-indole-2,3-dione

2-hydroxy-1-phenyl-ethanone

→

6-fluoro-3-hydroxy-2-phenyl-quinoline-4-carboxylic acid

Rendimiento 21.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto prepare a solution
2. 2
   Lavadothe precipitated crystal was washed with methanol and water

Procedimiento

5-Fluoro-1H-indole-2,3-dione (1.19 g) and 2-hydroxy-1-phenyl-ethanone (2.25 g) were dissolved in methanol (70 ml) to prepare a solution. Sodium hydroxide (4.82 g) and water (30 ml) were added to the solution, and the mixture was stirred at room temperature overnight. Dilute hydrochloric acid was added to the reaction solution, and the precipitated crystal was washed with methanol and water to give 6-fluoro-3-hydroxy-2-phenyl-quinoline-4-carboxylic acid (427 mg, yield 21%).

Fuente