Reacción #315918

Ecuación de reacción

4-Chloro-6,7-dimethoxyquinoline

2-bromo-3-pyridinol

→

title compound

Rendimiento 6.0%

4-(2-Bromo-pyridin-3-yloxy)-6,7-dimethoxyquinoline

Rendimiento 6.0%

Disolventes

o-dichlorobenzene

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction solution was cooled to room temperature
2. 2
   Otrothe solvent was then removed by distillation under the reduced pressure
3. 3
   Otrothe residue was purified by column chromatography

Procedimiento

4-Chloro-6,7-dimethoxyquinoline (226 mg), 2-bromo-3-pyridinol (250 mg), and 4-dimethylaminopyridine (400 mg) were suspended in o-dichlorobenzene (10 ml), and the suspension was stirred at 140° C. for 2 hr. The reaction solution was cooled to room temperature, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using acetone-chloroform to give the title compound (21 mg, yield 6%).

Fuente