Reacción #314594
ord-845082f05d9a4e1696ef1f36e0648b77
Ecuación de reacción
methyl-indole-6-carboxylate
ethylmagnesium bromide
product
2,2,3,3-tetramethylcyclopropanecarbonyl chloride
→
title compound
Rendimiento 40.0%
3-(2,2,3,3-Tetramethyl-cyclopropanecarbonyl)-1H-indole-6-carboxylic acid methyl ester
Rendimiento 40.0%
Reactantes
Reactivos
Disolventes
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Procedimiento
A mixture of methyl-indole-6-carboxylate (2.0 g, 11.4 mmol), ethylmagnesium bromide (1.0 M solution in THF, 14 mL, 14 mmol), zinc chloride (1.0 M solution in Et2O, 14 mL, 14 mmol) and the product of Example 1A (17 mmol) in 30 mL of dichloromethane was processed as described in Example 1B to provide the title compound (1.35 g, 4.5 mmol, 40% yield). MS (DCI/NH3) m/z 300 (M+H)+.