Reacción #313907

ord-03c23756543f4e40bdae5dcaf5bca756

Ecuación de reacción

Fc1cnc(Cl)nc1Nc1ccc2c(c1)OCCO2
2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine
NCC1COc2ccccc2O1
2,3-dihydro-1,4-benzodioxin-2-ylmethylamine
Fc1cnc(NCC2COc3ccccc3O2)nc1Nc1ccc2c(c1)OCCO2
N2-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-2,4-pyrimidinediamine

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otrowere reacted

Procedimiento

In like manner to the preparation of N4-(3-aminophenyl)-N2-[2-(methoxycarbonyl)-benzofurane-5-yl]-5-fluoro-2,4-pyrimidinediamine, 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine and 2,3-dihydro-1,4-benzodioxin-2-ylmethylamine were reacted to give N2-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-2,4-pyrimidinediamine. LCMS: ret. time: 22.49 min.; purity: 87.6%; MS (m/e): 411.01 (MH+).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07557210B2uspto-grants-2009_07