Reacción #313601

Ecuación de reacción

H2O

benzyl 4-methyl-2-(methylthio)-5-pyrimidinecarboxylate

m-chloroperbenzoic acid

→

benzyl 4-methyl-2-(methylsulfinyl)-5-pyrimidinecarboxylate

Rendimiento 84.0%

Disolventes

AcOEt

AcOEt

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadothe organic layer was washed with saturated NaHCO3 solution, brine
2. 2
   Secadodried over MgSO4
3. 3
   OtroThe solvent was evaporated in vacuo

Procedimiento

A solution of benzyl 4-methyl-2-(methylthio)-5-pyrimidinecarboxylate (3.6 g) and m-chloroperbenzoic acid (P=75%) (2.72 g) in AcOEt (30 ml) was stirred at ambient temperature for 2 hours. The reaction mixture was poured into a mixture of AcOEt and H2O and the organic layer was washed with saturated NaHCO3 solution, brine and dried over MgSO4. The solvent was evaporated in vacuo to give benzyl 4-methyl-2-(methylsulfinyl)-5-pyrimidinecarboxylate (3.2 g)

Fuente