Reacción #313240

Ecuación de reacción

8-(1-ethyl-propyl)-3-(7-isopropenyl-2-methyl-benzo[b]thiophen-3-yl)-2,6-dimethyl-imidazo[1,2-b]pyridazine

Et2Zn

ClCH2I

→

title compound

Rendimiento 12.5%

8-(1-ethyl-propyl)-2,6-dimethyl-3-[2-methyl-7-(1-methyl-cyclopropyl)-benzo[b]thiophen-3-yl]-imidazo[1,2-b]pyridazine

Rendimiento 12.5%

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITat RT for 1 h
2. 2
   TemperaturaThe reaction is cooled to 0° C.
3. 3
   Otroquenched with sat. NH4Cl (10 mL)
4. 4
   workup.ADDITIONdiluted with H2O (15 mL)
5. 5
   Extracciónextracted with EtOAc (3×30 mL)
6. 6
   Secadodried with Na2SO4
7. 7
   Filtraciónfiltered
8. 8
   Concentraciónconcentrated
9. 9
   OtroPurification of the crude material

Procedimiento

A solution of 8-(1-ethyl-propyl)-3-(7-isopropenyl-2-methyl-benzo[b]thiophen-3-yl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (97 mg, 0.24 mmol) in CH2Cl2 (5 mL) is cooled to 0° C., treated with 1.0 M Et2Zn (1.2 mL, 1.2 mmol) and ClCH2I (176 μL, 2.4 mmol). The reaction is stirred at 0° C. for 30 min, then at RT for 1 h. The reaction is cooled to 0° C., quenched with sat. NH4Cl (10 mL); diluted with H2O (15 mL); extracted with EtOAc (3×30 mL); dried with Na2SO4, filtered and concentrated. The crude material is subjected to the same condition to ensure the conversion is completed. Purification of the crude material using silica gel chromatography gives the title compound (12.4 mg, 0.03 mmol, 12%). 1H NMR (CDCl3): δ 0.80-0.84 (m, 2H), 0.92 (t, J=6.9 Hz, 6H), 0.97-1.11 (m, 2H), 1.51 (s, 3H), 1.79-1.94 (m, 4H), 2.41 (s, 3H), 2.43 (s, 3H), 2.46 (s, 3H), 3.22-3.54 (m, 1H), 6.69 (s, 1H), 7.07 (d, J=7.5 Hz, 1H), 7.21 (t, J=7.5 Hz, 1H), 7.26 (d, J=7.5 Hz, 1H) ppm. ES-MS (m/z): calcd for C26H31N3S (M+H)+: 418.6. found: 418.3.

Fuente