Reacción #312770

ord-ef3174525d0440d6b3205b0527f8bb08

Ecuación de reacción

CC(C)(C)OC(=O)N1Cc2ccc(I)cc2C1
5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
Cl.FC1(F)CCNCC1
4,4-difluoropiperidine hydrochloride
→
CC(C)(C)OC(=O)N1Cc2ccc(N3CCC(F)(F)CC3)cc2C1
5-(4,4-Difluoro-piperidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

Reactantes

CC(C)(C)OC(=O)N1Cc2ccc(I)cc2C1
5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
Cl.FC1(F)CCNCC1
4,4-difluoropiperidine hydrochloride

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepared in analogy to Example A3(d) from 5-iodo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (Example A38(b)) and 4,4-difluoropiperidine hydrochloride. Yellow solid. MS (m/e): 339.1 ([M+H]+, 100%).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07557114B2uspto-grants-2009_07