Reacción #312608

Ecuación de reacción

1-(phenylsulfonyl)-4-piperzin-1-yl-1H-indole

2-methylthio-2-imidazoline hydroiodide

N,N-diisopropylethylamine

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title product

4-[4-(4,5-Dihydro-1H-imidazol-2-yl)-piperazin-1-yl]-1-(phenylsulfonyl)-1H-indole

Disolventes

dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperatura, cooled
2. 2
   Concentraciónconcentrated in vacuo
3. 3
   Otroto give a residue
4. 4
   OtroThe residue is purified by HPLC

Procedimiento

A solution of 1-(phenylsulfonyl)-4-piperzin-1-yl-1H-indole (71 mg, 0.18 mmol) in dioxane is treated with 2-methylthio-2-imidazoline hydroiodide (52.7 mg, 0.22 mmol) and N,N-diisopropylethylamine (62 μl, 0.36 mmol), heated at 50° C. for 16 hr., cooled and concentrated in vacuo to give a residue. The residue is purified by HPLC to give the title product, 15 mg, identified by HPLC and mass spectral analyses (2.57 min; 410 M+H) using the LCMS conditions described in Table I.

Fuente