Reacción #310320

Ecuación de reacción

4-hydroxy-6-methyl-2-trichloromethylpyrimidine

triethylamine

crotonyl chloride

→

pure product

Rendimiento 45.0%

4-Crotonoxy-6-Methyl-2-Trichloromethylpyrimidine

Rendimiento 45.0%

Disolventes

diethyl ether

—

petroleum ether

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was refluxed for 15 hours
2. 2
   Filtraciónfiltered
3. 3
   Concentraciónthe filtrate was concentrated in-vacuo
4. 4
   Otroto give a viscous oil as residue
5. 5
   OtroRecrystallization from isopropyl alcohol

Procedimiento

To a solution of 3.0 g (0.02 mole) 4-hydroxy-6-methyl-2-trichloromethylpyrimidine and 1.3 g (0.02 mole) triethylamine in 75 ml diethyl ether was added 1.4 g (0.02 mole) crotonyl chloride. The reaction mixture was refluxed for 15 hours and filtered, and the filtrate was concentrated in-vacuo to give a viscous oil as residue. Trituration with petroleum ether caused the oil to solidify. Recrystallization from isopropyl alcohol gave 1.8 g (45% yield) of pure product; m.p. 55° C.

Fuente