Reacción #307249

Ecuación de reacción

6-(4-Chlorophenyl)-N-cyclopropylpyrimidine-4,5-diamine

2-ethylnicotinoyl chloride

NaHCO3

→

N-[4-(4-Chlorophenyl)-6-cyclopropylaminopyrimidin-5-yl]-2-ethylnicotinamide

Disolventes

DCM

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe reaction mixture was warmed to room temperature
2. 2
   Otrothe organic phase was separated off
3. 3
   Concentraciónconcentrated under reduced pressure

Procedimiento

6-(4-Chlorophenyl)-N-cyclopropylpyrimidine-4,5-diamine (1.00 g, 3.83 mmol) was initially charged in a mixture of DCM (3.20 ml) and pyridine (0.93 ml) and cooled to 0° C. Solid 2-ethylnicotinoyl chloride (780 mg, 4.60 mmol) was added, and the reaction mixture was warmed to room temperature and stirred for another hour. After addition of semisaturated NaHCO3 solution, the organic phase was separated off and concentrated under reduced pressure.

Fuente