Reacción #305073

Ecuación de reacción

ethyl 3-(4-pyrimidinyl)-3-oxopropionate

ethyl 3-(pyridin-4-yl)-3-oxopropionate

2-(2-amino-3-methyl-3,4,5,6-tetrahydropyridin-3-yl)-1H-isoindole-1,3(2H)-dione hydrochloride

→

(+/−)2-(1-methyl-5-oxo-7-pyrimidin-4-yl-1,2,3,4,4a,5-hexahydronaphthalen-1-yl)-1H-isoindole-1,3(2H)-dione

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroprepared by analogy to the method
2. 2
   Otrowas obtained as a white powder

Procedimiento

By analogy with the method described in example 1 (step 1.3), using ethyl 3-(4-pyrimidinyl)-3-oxopropionate (prepared by analogy to the method described in patent DE 2705582) in place of ethyl 3-(pyridin-4-yl)-3-oxopropionate and using 2-(2-amino-3-methyl-3,4,5,6-tetrahydropyridin-3-yl)-1H-isoindole-1,3(2H)-dione hydrochloride (1:1) the compound was obtained as a white powder.

Fuente