Reacción #3049

Ecuación de reacción

Water

Allyl bromide

2-t-butylphenol

potassium carbonate

→

2-(1,1-dimethylethyl)phenoxypropene

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux temperature for 50 hours
2. 2
   Otrothe resulting layers were separated
3. 3
   ExtracciónThe aqueous layer was extracted with 600 ml of diethyl ether
4. 4
   Extracciónextract
5. 5
   Secadothe resulting solution was dried over sodium sulfate overnight
6. 6
   OtroAfter sodium sulfate removal
7. 7
   Otrothe solvent was evaporated
8. 8
   Otroto provide

Procedimiento

Allyl bromide (69.2 ml), 2-t-butylphenol (122.9 ml) and potassium carbonate (121.6 g) were stirred in 265 ml of acetone at reflux temperature for 50 hours and then cooled to 35° C. Water (600 ml) was added and the resulting layers were separated. The aqueous layer was extracted with 600 ml of diethyl ether. The organic layer was combined with the aqueous layer's ether extract and the resulting solution was dried over sodium sulfate overnight. After sodium sulfate removal, the solvent was evaporated to provide, after further workup, 147 g of the subtitled intermediate.

Fuente