Reacción #303886

Ecuación de reacción

triethylamine

4-bromobenzyl bromide

thiomorpholine-1,1-dioxide hydrochloride

→

4-(4-Bromo-benzyl)-thiomorpholine-1,1-dioxide

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe reaction mixture is partitioned between CH2Cl2 and H2O
2. 2
   ExtracciónThe aqueous phase is re-extracted four times with CH2Cl2
3. 3
   LavadoThe combined organic extracts are washed with water, saturated brine
4. 4
   Secadodried over Na2SO4
5. 5
   Filtraciónfiltered
6. 6
   Concentraciónthe filtrate is concentrated in vacuo
7. 7
   Otroto afford
8. 8
   Otroafter drying in HV
9. 9
   Otrothe title compound which is used in the next step without further purification

Procedimiento

2.18 ml (15.5 mmol) of triethylamine are added to a colorless suspension of 1.28 g (5 mmol) of 4-bromobenzyl bromide and 944 mg (5.5 mmol) thiomorpholine-1,1-dioxide hydrochloride in 15 ml DMF. After 3 h at RT, the reaction mixture is partitioned between CH2Cl2 and H2O. The aqueous phase is re-extracted four times with CH2Cl2. The combined organic extracts are washed with water, saturated brine, dried over Na2SO4, filtered and the filtrate is concentrated in vacuo to afford, after drying in HV, the title compound which is used in the next step without further purification.

Fuente