Reacción #303493

Ecuación de reacción

N,O-Dimethylhydroxylamine hydrochloride

1-trifluoromethylcyclopropane-1-carboxylic acid

EDC

hydroxybenzotriazole hydrate

N-methylmorpholine

→

N-methoxy-N-methyl-1-(trifluoromethyl)cyclopropanecarboxamide

Disolventes

ethyl acetate

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed successively with 2 M hydrochloric acid, saturated aqueous sodium bicarbonate and brine
2. 2
   Secadodried (sodium sulfate)
3. 3
   Concentraciónconcentrated

Procedimiento

N,O-Dimethylhydroxylamine hydrochloride (7.17 g, 73.5 mmol) was added to an ambient temperature solution of 1-trifluoromethylcyclopropane-1-carboxylic acid (10.3 g, 66.8 mmol), EDC (15.4 g, 80.2 mmol), hydroxybenzotriazole hydrate (12.28 g, 80.2 mmol) and N-methylmorpholine (36.7 mL, 33.8 mmol) in methylene chloride (50 mL) at ambient temperature. After stirring at ambient temperature overnight, the reaction mixture was poured into ethyl acetate and washed successively with 2 M hydrochloric acid, saturated aqueous sodium bicarbonate and brine, dried (sodium sulfate) and concentrated to afford N-methoxy-N-methyl-1-(trifluoromethyl)cyclopropanecarboxamide which was used in the subsequent step without further purification.

Fuente