Reacción #302892

Ecuación de reacción

2,3-dimethylbenzylamine

2-chloroethylisothiocyanate

→

title compound

Rendimiento 76.0%

((2,3-dimethylphenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

Rendimiento 76.0%

Disolventes

1,4-dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato cool
2. 2
   Otroa solid precipitate that had formed
3. 3
   Filtraciónwas collected by filtration
4. 4
   LavadoThe solid was rinsed with diethyl ether
5. 5
   Otrowas dried under reduced pressure

Procedimiento

Under a dry nitrogen atmosphere, a stirred mixture of 5.56 grams (0.041 mole) of 2,3-dimethylbenzylamine and 5.0 grams (0.041 mole) of 2-chloroethylisothiocyanate in 100 mL of 1,4-dioxane was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 8.0 grams of the title compound. The NMR spectrum was consistent with the proposed structure.

Fuente